The TumorImager™ is a first of its kind device designed to accurately and efficiently measure the size of subcutaneous xenograft tumor models in mice and rats. It is capable of measuring the volume of multiple, irregular and even necrotic tumors.
The sensor head with mount can be detached from the controller base unit and placed inside a laboratory hood to maximize available space. In order to ensure optimal ergonomics for each user, the sensor head can also be adjusted in multiple axes to reduce the risk of repetitive strain injury.
The TumorImager™ is an image acquisition and processing system that utilizes a laser/camera system to project a line over the animal being measured. The animal is held beneath the positioning mask so that the laser scans over it and the camera captures the data. It then creates a point cloud representing the x, y, and z coordinates defining the animal surface area. The z-axis information is obtained from the triangulation of the data points. Using patented algorithms, the tumor is then segmented and the volume calculated. The working principle is shown to the right.
Since it does not assume a predefined shape (as in the case of caliper based measurements), the TumorImager™ can measure the volume of any irregular shaped tumor, including necrotic tumors. Many animals develop necrotic tumors near the end of a study. Accurate measurements of these types of tumors can only be made with the TumorImager™.
Please see the paper “A Structured Light-based System for Scanning Subcutaneous Tumors in Laboratory Animals by I. C. Girit et al, Comparative Medicine, Vol 58, No 3 , p264-270” for further information.
For users, the measurement procedure with this new device is simple; in fact it is easier than using calipers. The process is:
This process takes less time than making caliper measurements.
|Measurement range, x axis||41 mm|
|Start of measurement range along x axis||2.5 mm (before the mask)|
|End of measurement range along x axis||37.5 mm (after the mask)|
|Camera working distance||100 mm|
|Maximum tumor size along x-y||25 mm|
|Maximum tumor height||20 mm|
|Tumor scan time||~1 s|
|Resolution, z axis||0.04% (10 µm)|
|Linearity, z axis (±3 sigma)||0.2% (50 µm)|
|Light source||Laser diode 655 nm, 15 mW|
|Laser class||Class 2M|
|Computer Interface||Firewire and USB 2.0|
|Interface cable length||Up to 6ft|